An NIH funded postdoctoral scientist position is available in the Department of Pharmacology and Chemical Biology at Baylor College of Medicine. The successful candidate will participate in our structure based drug discovery program targeting signaling proteins in the Nitric Oxide-cGMP signaling cascade using X-ray crystallography and cryoEM. These enzymes modulate the cellular level of cGMP or the cellular response to this crucial secondary messenger and represent therapeutic targets for treating many hypertensive diseases, such as arterial and pulmonary hypertension, heart failure and erectile dysfunction. The successful candidates must have PhD degree and have strong skills in molecular biology, protein purification and macromolecular crystallography. Preference will be given to those who have a strong drive and motivation and the ability to design, plan and interpret experiments.